| Shandong's coastal areas have developed economy and dense population. However, the terrain is low in some areas and the standard of many seawalls are fifty years once. In the event of a hundred-year storm surge inundation, there will be enormous economic losses. Therefore, an assessment of the economic vulnerability of Shandong's coastal areas will help to take disaster mitigation and prevention measures. In this paper, DEM, remote sensing data and GIS are used to evaluate the impact of the once-in-one-hundred tide bursts on the economic vulnerability of Shandong coastal areas. The results of the study are as follows: The impact range of submerged hundred-year tidal level is mainly concentrated in Weifang, Dongying and Binzhou; Longkou, Fushan, Zhifu, Laishan and Weihai cities, Donggang and Lanshan. The densities of GDP in Binzhou, Dongying, Weifang, Laizhou, Zhaoyuan, Penglai, Muping, Haiyang, Laiyang, Jimo and Pingdu are relatively low. The submerged deeper areas are concentrated in Weifang, part of Dongying, Jiaozhou Bay and Rizhao coastal areas. The results show as follows: (1) The areas with extremely high economic vulnerability are distributed in Hanting and Chengyang districts; the areas with very high economic vulnerability are Huangdao district; the areas with high economic vulnerability include Donggang district, Laizhou city, Shouguang city, Changyi county, Guangrao county and Dongying district. (2) Causes of vulnerability: Hanting district, Shouguang city, Changyi county, Guangrao county, Dongying district and Laizhou city have large submerged area, large inundation depth; Huangdao district, Donggang district and Chengyang have large GDP density, large submerged depth. (3) Preventing storm surge disasters can be achieved by strengthening the construction of early warning and emergency plans, strengthening the construction of early warning and emergency plans, adjusting the economic distribution, strengthening the conservation of Baish Willow wetland and actively expanding the scope of Baisha Willow wetland.